Biochanin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Biochanin A 抑制小鼠、大鼠和人 FAAH 对 0.5 μM AEA 的水解，IC50 分别为 1.8、1.4 和 2.4 μM。

Biochanin A inhibits the hydrolysis of 0.5 μM AEA by mouse, rat and human FAAH with IC50 s of 1.8, 1.4 and 2.4 μM respectively. FAAH is inhibited by Biochanin A with a pIC50 value of 6.21±0.02, corresponding to an IC50 value of 0.62 μM. Biochanin A produces significant inhibition of the URB597-sensitive tritium retention at high nanomolar-low micromolar concentrations. Experiments are run with human FAAH and 0.5 μM [3H]AEA with assay conditions giving these higher utilization rates, the activity is still inhibited by Biochanin A, Genistein, Formononetin and Daidzein in the low micromolar range (IC50s of 6.0, 8.4, 12 and 30 μM, respectively).

——

——

NSC 123538

Proteasome/Ubiquitin

Other Targets

EGFR| FAAH (human)| FAAH (mouse)| FAAH (rat)

Inflammation/Immunology

——

491-80-5

284.26

C16H12O5

>98% (HPLC)

Ethanol: 9 mg/mL (31.66 mM); DMSO: 57 mg/mL (200.52 mM)

O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(O)=CC(O)=C13

5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years